Nicotinamide Riboside (NR) Could Have a Positive Impact on COVID-Related Cardiovascular Diseases.


Researchers suspect that the circulating plasma from COVID-19 infections is responsible for vascular blood vessel lining dysfunction, and constriction of blood vessels in the heart, which can cause chronic chest pain. This is one of an array of symptoms reported with what’s come to be known as long COVID. 


Freeberg, Kaitlin A., et al. “NAD+-Boosting Compounds Enhance Nitric Oxide Production and Prevent Oxidative Stress in Endothelial Cells Exposed to Plasma from Patients with COVID-19.” Nitric Oxide, volumes 140–141, November 2023, pages 1-7, ISSN 1089-8603.


To investigate whether blood plasma derived from COVID-19 patients causes endothelial cell dysfunction, and explore the protective effects of NR and NMN on COVID-19-induced endothelial cell dysfunction and oxidative stress.


  • Exposing blood vessel cells to plasma taken from COVID-19 patients caused cell dysfunction, leading to reduced nitric oxide production, increased oxidative stress, and decreased NAD+ levels.
  • Treatment of blood vessel lining cells with equal doses of NR and nicotinamide mononucleotide (NMN) alone both prevented COVID-19 plasma-induced dysfunction by restoring nitric oxide production and reducing oxidative stress, compared to that of cells exposed to control plasma.

(Source: Chromadex)

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