Recently, a research team led by Academician Ning Guang and Professor Wang Weiqing from Shanghai Jiao Tong University School of Medicine published a milestone study in Cell Metabolism. The study is the first to reveal that in overweight/obese patients with type 2 diabetes, the effectiveness of Akkermansia muciniphila supplementation depends on its baseline levels in the gut.
In plain words, the effect of AKK bacteria depends on the number of AKK bacteria in the patient’s intestines. If the number is small, the effect after supplementation is significant, and it can reduce weight, fat and blood sugar; if the number is large, the effect after supplementation is mediocre.
It proves that supplementation of AKK bacteria can resist sugar and reduce weight, and it also avoids a one-size-fits-all approach, such as those with high AKK bacteria in the body do not need to be supplemented.
Baseline AKK bacteria <1.5% is low:
After supplementation, the colonization rate increased, body weight, visceral fat, and glycosylated hemoglobin (HbA1c) decreased significantly, and fat oxidation capacity increased.
Baseline AKK bacteria ≥1.5% is high:
The colonization rate of the flora is low and no obvious metabolic improvement effect is shown. (Source: AKK Jun)
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