Recently, Zhu Xiangjia, Lu Yi, and their team from the Eye, Ear, Nose, and Throat Hospital affiliated with Fudan University published a research paper in Cell Discovery titled “Gut Microbiota-Derived Indole-3-Acetic Acid Suppresses High Myopia Progression by Promoting Type I Collagen Synthesis.” Through in-depth analysis of gut microbiota and metabolites in patients with high myopia, they found a strong correlation between the colonization of probiotic Akkermansia, the levels of gut-derived metabolite indole-3-acetic acid (3-IAA), and the degree of myopia progression. Daily supplementation of 3-IAA was shown to help prevent or slow down the progression of myopia in mice with high myopia by inhibiting scleral remodeling. This discovery offers potential for the development of novel strategies for myopia prevention and treatment. Source: Singularity Hub
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